Resveratrol is poorly absorbed, and human trials show small, inconsistent metabolic effects — it can even blunt some exercise adaptations. What the trials found and what the red-wine story leaves out.
Fisetin is a flavonoid found in strawberries that screened as the most potent natural senolytic in lab tests — but a major human trial is still running, and the bioavailability problem is real.
Spermidine appears to induce autophagy, the cellular recycling process linked to longevity, and it is abundant in wheat germ, aged cheese and natto. Animal data are strong; human evidence is mostly observational.
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