Longevity
Lifespan extension research has moved from fringe to serious science. This section tracks the compounds and protocols with real human evidence — NAD+ precursors, rapamycin, senolytics, fasting protocols — and separates the promising from the premature. We read the mouse studies so you don't extrapolate from them incorrectly.
SS-31 (Elamipretide): The Mitochondrial Peptide Targeting the Root of Aging
SS-31 targets cardiolipin in the inner mitochondrial membrane and restores youthful mitochondrial function...
Epithalon: The Telomere Peptide and the Science of Cellular Aging
Epithalon is a tetrapeptide that activates telomerase and may extend telomere length. Decades of research...
Apigenin: The Chamomile Compound That Protects NAD+, Promotes Sleep, and Supports Testosterone
Apigenin is better known as a component of chamomile tea. But at supplemental doses it also inhibits CD38...
Resveratrol: The Red Wine Molecule That Disappointed Scientists — and Why It's Still Worth Understanding
Resveratrol gets more press than almost any longevity compound — but the clinical story is more nuanced...
NMN vs NR: Which NAD+ Precursor Actually Works?
Both raise NAD+. Both promise to slow aging. But NMN and NR are not the same — here's what the clinical...
Zone 2 Cardio: The Longevity Workout, Fact-Checked
Zone 2 - easy, conversational cardio - is a longevity favorite. The fitness-and-mortality link is rock...
NAD+ and NMN: The Longevity Supplement, Examined
NMN is sold as an anti-aging breakthrough. The human evidence is early and modest. Here is what trials...
Intermittent Fasting and Time-Restricted Eating: What Works
Intermittent fasting can help with weight and metabolic health, largely by helping you eat less. Here is...
VO2 Max: The Strongest Predictor of Lifespan
Among all the biomarkers people track, cardiorespiratory fitness may be the single most powerful predictor...
Metformin for Longevity: The Great Debate
A cheap, decades-old diabetes drug has become the unlikely centerpiece of the longevity world—but the...
Fisetin: A Senolytic in Your Fruit Bowl
Fisetin is a flavonoid found in strawberries that screened as the most potent natural senolytic in lab...
Senolytics: Clearing Out the Zombie Cells
Senescent cells accumulate with age and poison their neighbors — and a new class of drugs aims to clear...
Spermidine and the Renewal of Cells
Spermidine triggers autophagy — the cellular self-cleaning process linked to longevity — and unlike most...
Rapamycin and the Longevity Frontier
Rapamycin is the most reproducible lifespan-extending drug in animal research — and the most genuinely...
Taurine: The Longevity Amino Acid
A single high-profile study put taurine on the longevity map by extending lifespan in mice — but the human...